Vyome envisages a future where contemporary knowledge of host pathogen relationship of the skin microbiome at a molecular and genomic level can be fully exploited in designing novel therapies to address the huge unmet need and growing concern of antibiotic resistance. Genomic understanding of the pathogens will be utilized to fully harness the potential and to significantly enhance the efficacy of anti-microbial agents. In pursuit of achieving these goals, Vyome plans to leverage its technology platforms using the functional genomics which are very versatile in nature with multiple potential usages-
Acne is caused by a bacteria, Propionibacterium acne. Over 240 million patients suffer from mild to moderate acne globally and are treated with antibiotics. Over 100 million patients are resistant to current antibiotics used to treat acne.
Vyome has built a library of Propionibacterium acne isolates from patients, and has built genomic understanding of the drivers of resistance. Based on this understanding, Vyome is rapidly advancing its lead molecule VB 1953 to the clinics for the treatment of drug-resistant acne. VB 1953 also exerts an anti-inflammatory effect and retards the development of resistance. Vyome merges this next-generation antibiotics with an IP-protected microtechnology gel system that ensures the Drug is retained at the site of infection and minimizes systemic exposure.
New generation of antibiotics, called as Dual Action Rational Therapeutics (DARTSTM) inhibit multiples targets in the bacterial DNA replication and protein translation machinery, and is therefore designed to retard the development of future resistance. These novel antibiotics exhibit excellent activity in antibiotic-resistant Propionibacterium acnes, and also against Staphylococcus epidermidis, which cause over 90% of all implant-related infections. DARTS are being tested against acute infections during surgical interventions or other life threatening infections.
Molecular Replacement Therapeutics (MRTTM) revolves around the idea of substituting essential biomolecules in the tissue micro-environment, where an infecting microbe is thriving, with agents that are deleterious to the growth of the pathogen. MRTTM therefore act as potentiators of existing antifungal agents. In clinical studies, MRTTM outperforms current gold standards in treatments of skin fungal infections such as scalp seborrheic dermatitis.
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